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Prescription by general practitioners. NRT can be used by all smokers with a few cautions and contraindications the type and strength are individually determined by personal and practical issues, for example, ease of use or smoking history Table 2 ; . NRT is initially prescribed for 12 weeks with a second prescription given if the smoker demonstrates a continuing effort to stop smoking, with the aim of reducing nicotine dependence over time. If a quit attempt is unsuccessful, a further attempt will not usually be NHS-funded within 6 months. The atypical antidepressant bupropion Yban ; has been shown to be effective in smoking cessation by reducing the. See first look suggests some benefit from coq10 , june 200 ; a new double-blind study will assess the effectiveness of coq10 on saving motor units, using a neuroimaging technique. The Secretariat is aware that a CE threshold for projects in the MDI sub-sector has not been established by the Executive Committee. However, the Secretariat is correlating the calculated CE at the plant level with the potential sustainability of the manufacturing plants.
You’ re also fortunate you have someone who is skilled enough to get down into that large jointwith a needle. Stay off the grapefruit ; juice! Amlodipine + perindopril a good bet for hypertension? Hypertension Guidance Update. Some are more equal than others Vitamins for life??? Statins hailed as the new aspirin Short, sharp, potent What Next? Reversal of fortune for beta-blockers in heart failure Fractures and the Elderly. Androgen deprivation treatment is associated with risk of fracture. Warning of potential liver injury with Black Cohosh. Are there alternatives to HRT for menopausal symptoms? Bell's Palsy - early treatment is the best. Restless legs Timely help with COPD! ZYBAN - more smoke DOPAMINE AGONISTS OUTPACE LEVODOPA.

We continued our transformation to profitability with our second consecutive profitable quarter, " said Barry R. Edwards, Chief Executive Officer of IMPAX. "Although our profit was more modest this quarter than during the first quarter, owing to shipment timing, lower gross margins primarily due to changes in product mix, and research and development expense, we continue to see the benefits of past research efforts as highlighted by final FDA approval for our generic versions of Sinemet CR, Zyvan and Proamatine received during the quarter." a ; Date of Statement: This statement appears in the August 4, 2004 press and wellbutrin.
The authors' group has investigated protein chemistry and enzyme chemistry involving glutathione and enzymes related to reactive oxygen species.1 ; In particular, we purified various -glutamyltranspeptidases, an enzyme that degrades glutathione from various tumor tissues and reported that this enzyme is highly activated in hepatocarcinoma and found that a purified enzyme from hepatoma tissues contains a unique structure designated as a bisecting GlcNAc. This was accomplished in collaboration with Dr. Akira Kobata's group.2 ; After this report was published unique cancer specific glycosylation patterns became of interest for many researchers and a number of reports have been published. Among those, the 1-6 fucosylation of -fetoprotein AFP ; , a well known clinical tumor marker, is a good ex.

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TYPHOID CARRIER RECORD Name Date of Birth Sex Race Street Address or Location How Long City or Town Parish Previous Address City or Town Parish Date of Diagnosis Occupation at Time of Diagnosis Name and Address of Present Employer History of Typhoid Fever? Yes No If yes, where when If no, method of acquisition of S. typhi travel, food, etc. ; Food Related Work Activity Personal Hygiene: Good Fair Poor Willingness to carry out instruction: Yes No Water supply: City Individual Protected well or spring Unprotected well or spring and prozac. Zyban side effects ranolazine in judaea zyban side effects wept but for vendors. Plastic pitcher pours water while holding back ice and features pop-off tabs that let the user open lid with a quick flick of the thumb. Clear lid. 1000 cc. Item No. Description DYND80521 Gold DYND80535 Mauve Accessories for Bedside Carafes Fits 80535 and 80521 pitchers. ; DYND80526 White Foam Liner DYND80528 Graduated Plastic Liner DYND80532 White Foam Outer Jacket Replacement Lids For bedside carafes 80535 and 80521. ; DYND80565 Replacement lids Pkg 100 cs 100 cs and desyrel.

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If you practice in an intervention area that offers provider counseling plus smoking cessation drugs, you may be prescribing bupropion zyban only ; to your patients who are eligible, or you might be recommending the nicotine patch and effexor. Withdrawal symptoms and side effects Some smokers confuse symptoms of withdrawal from tobacco with the side effects of NRT. They may become tense, agitated, depressed, have disturbed sleep or crave cigarettes when using NRT. These can be symptoms of nicotine withdrawal. This can happen when the nicotine from the NRT has not properly replaced the nicotine from cigarettes. Different types of NRT can be combined to enhance the success, for example patch plus one of the following: 1. Gum 2. Lozenge 3. Sublingual tablet 4. Inhaler. Some people do experience side effects, but these are usually mild. Side effects can include: A rash on the skin where the nicotine patch is worn. Moving the patch to a new area of skin each day will help reduce skin irritation, and there are also medicated skin creams available Hiccups Indigestion Mouth irritation. If you are concerned, talk to your doctor. What is bupropion Zybsn ; ? Bupropion is a non-nicotine medication that helps people stop smoking. It is available only on prescription so you need to visit your doctor. Bupropion can be combined with NRT to help with quitting. Talk to your doctor about the suitability of this treatment. Bupropion may not be appropriate for all smokers and is not recommended for people with seizure disorders, those on certain medications for depression, or those with a history of manic-depressive illness. At the time of publication Zybam is the only form of bupropion available in Australia. For more information talk to your doctor or pharmacist. Call the Quitline 131 848 for free, ongoing counselling while you quit. Other strategies Other strategies that may help you when you decide to quit are: Counselling. Developing a quit plan which includes: 1 Setting a date to quit. 2 Reviewing past experience to determine what worked and what did not work. 3 Identifying potential problems and ways to deal with them. 4 Enlisting the support of family and friends. 5 Quitting with a friend. 6 Reducing alcohol and caffeine use in the first two weeks. Oral Polio Vaccine Recent media attention has highlighted recall of all batches of oral polio vaccine OPV ; manufactured by Medeva Evans ; in the UK and Ireland. This recall was initiated because the product was manufactured using a growth medium containing material of UK bovine origin. European guidelines state that the manufacturing process for all medicinal products should not use bovine material from countries where there are known cases of BSE. This vaccine has not been available since mid-September and the last batch expired on the 20th of September 2000. An alternative source of OPV is available from SmithKline Beecham SKB ; and is currently the only polio vaccine supplied under the Department of Health and Children's National Immunisation programme. The IMB has received confirmation from SKB that the product was manufactured using non-UK sourced foetal calf serum. The IMB considers any risk associated with the Medeva Evans ; vaccine is exceedingly small. The vaccination programme should continue using the polio vaccine manufactured by SKB. Following this recall, letters have circulated to Directors of Community Care, GPs, Paediatricians, Infectious Disease Specialists, Microbiologists, Public Health Specialists, Vaccine Travel Clinics and the National Disease Surveillance Centre advising them about the reasons for the recall and procedures for return of any remaining stock. Bupropion Zuban ; Bupropion is a prescription medicine indicated as an aid to smoking cessation, in combination with motivational support in nicotine-dependent patients. It was authorised by the Irish Medicines Board IMB ; in June 2000. A risk of seizures Drug Safety - December 2000 - Issue No. 11 and emsam. It is remarkably safe having been used on men with enlarged prostate glands for over 15 years with no serious side effects.

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USA The Group earned 53 per cent of total pharmaceutical revenue in the USA in the year, recording a growth of 16 per cent. Advair Seretide launched in mid-April 2001 achieved sales of 328 million. Although this launch slowed sales growth of its constituent products, Flixotide Flovent and Serevent, combined sales of these three products amounted to 1, 179 million with growth of 52 per cent. In the CNS therapeutic area Seroxat Paxil, launched for generalised anxiety disorder in April, grew strongly and Wellbutrin continued its good growth record. Both of these products benefited from the growing anti-depressant market in the USA. Lamictal, indicated for epilepsy, grew 23 per cent. In the anti-bacterials sector Augmentin reflected gains in share of both the adult and paediatric markets. Growth was bolstered by the launch of the ES extra strength ; formulation, which is indicated for the treatment of children with acute otitis media middle ear infections ; . The combination treatment Trizivir was launched into the US market in late 2000. Sales in its first full financial year amounted to 115 million helping to produce 11 per cent sales growth in the HIV AIDS sector of anti-virals. Also in the anti-virals market, Valtrex for herpes showed a strong performance. Europe Europe region contributed 26 per cent of pharmaceutical sales with the largest market, France, showing strong growth. Good growth was recorded in other major markets including Italy, Spain and Central and Eastern Europe. Seretide was a major sales driver in the region although, as in the USA, this affected sales of its constituent products. Seretide Advair is now the largest product in Europe with sales of 441 million. In the CNS area Seroxat, coupled with the launch of Zyban in most markets, contributed most of the growth. Launches of Trizivir helped produce a 16 per cent growth in the HIV AIDS sector. In metabolic and gastro-intestinal, Zantac sales continued to decline in the face of increased generic competition. This was partially offset by the performance of Avandia with launches in a number of markets including the UK and Germany. Anti-bacterials declined one per cent reflecting generic competition for Augmentin and Amoxil. Vaccines showed no growth due to a decline in the hepatitis market in Germany, although sales improved in other European countries principally UK, Spain and Italy. In the Oncology area most of the growth was attributable to strong sales of Zofran in France and Germany offset by a decline in Hycamtin sales in most European countries. Rest of the World A 10 per cent sales growth in the Rest of the World region reflected strong growth in all major markets in this region. The market growth in Japan was driven by a number of therapeutic areas. The launch of the tablet form of Imigran in August 2001 and Seroxat in late 2000 were key drivers. The switch from Becotide to the newer product Flixotide and from Zovirax to the newer Valtrex contributed to the sales growth of the newer products but led also to a decline in the older products. In Canada significant growth was achieved by Seretide and Avandia, which was launched in March 2001. In other therapeutic areas, Trizivir for HIV treatment was launched in November and geodon.
April 2001; 11 2 ; Adverse drug reaction reporting - 2000: Part 1 Antiparkinsonian drugs and "sleep attacks" Rofecoxib Vioxx ; : a year in review Communiqu Warfarin and glucosamine: interaction Drugs of Current Interest January 2001; 11 1 ; Thioridazine Mellaril ; and mesoridazine Serentil ; : prolongation of the QTc interval Clopidogrel Plavix ; : hematological reactions Gentamicin ear drops and ototoxicity: update Drugs of Current Interest October 2000; 10 4 ; New influenza drugs: unexpected serious reactions Intravenous RhO [D] immune globulin [human]: suspected hemolytic renal adverse reactions Abboject Unit-of-Use Syringe: reports of malfunction Glucosamine sulfate: hyperglycemia Communiqu Ketotifen Zaditen ; : sleep apnea Diclofenac Voltaren Ophtha ; and ketorolac tromethamine Acular ; : corneal ulceration Drugs of Current Interest July 2000; 10 3 ; St. John's wort: harmful drug interaction Olanzapine Zyprexa ; : suspected serious reactions Sildenafil Viagra ; : cardiac risks New Bureau Name Citalopram Celexa ; and clarithromycin Biaxin ; : interaction Communiqu Itraconazole Sporanox ; : serum sickness-like disorder Drugs of Current Interest April 2000; 10 2 ; Adverse drug reaction reporting - 1999 Celecoxib Celebrex ; : 1 year later Correction - ticlopidine orlistat Xenical ; : pancreatitis Communiqu Drugs of Current Interest January 2000; 10 1 ; Cisapride Prepulsid ; : interactions Pemoline Cylert ; : market withdrawal Bupropion Zyban ; : update Communiqu HIV protease inhibitors: paronychia Gingko biloba: bleeding disorders Drugs of Current Interest.

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Zyban helps reduce your urge to smoke and can make quitting bearable. You and your doctor set a quit date. This treatment is taken while you're still smoking, but on your quit date you stop smoking and continue to take it as prescribed and cymbalta. All cause mortality plus admission to hospital for heart failure.

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Selected adverse events with an incidence of at least 1% of patients treated with zyban and more frequent than in the placebo group and seroquel and Buy cheap zyban. Federal Drug Administration 2002 ; , "The Drug Development Process: How the Agency Ensures that Drugs are Safe and Effective, " Publication # FS 025, U.S. Department of Health and Human Resources. Lichtenberg, F. 2002 ; "Social Returns to Pharmaceutical R&D" Exploring the economics of Biotechnology, Federal Reserve Bank of Dallas, Dallas, U.S.A Mansfield, E. 1994 ; , "Intellectual Property Protection, Foreign Direct Investment and Technology Transfer." International Finance Corporation, World Bank: Washington, DC, Discussion Paper 19. Murphy, K.M., and Topel, R., 2002 ; , "The Economic Value of Medical Research." Forthcoming in Exceptional Returns, eds. Kevin M. Murphy and Robert H. Topel. Chicago: University of Chicago Press. Myers, S.C., Shyam-Sunder, L., 1996 ; , "Measuring Pharmaceutical Industry Risk and Cost-of-Capital, " American Enterprise Institute, Washington Peck, C.C., 1997 ; "Drug Development: Improving the Process." Food and Drug Law Journal 52, 163167. Pugatch, M.P., 2004 ; , "Intellectual Property and Pharmaceutical Data Exclusivity in the Context of Innovation and Market Access, " University of Haifa, Israel Taylor, C.T. and Silberston, Z.A. 1973 ; , "The Economic Impact of the Patent System, " Cambridge, England, Cambridge University Press. Thomas, K.A, and al. 1998 ; , "A Study of Trends in Pharmaceutical Regulatory Approval Times for Nine Major Markets in the 1990's", Drug Information Journal 32, 787801 U.S. Congress, Office of Technology Assessment, 1993 ; , "Pharmaceutical R&D: Costs, Risks, and Rewards, " OTAH-522, U.S Government Printing Office, Washington, DC. CHAPTER FOUR Sequence of Events 7pm All of the evidence showed that Henri Paul believed he had finished work for the day when he left the Ritz Hotel. There were no plans for Dodi Al Fayed and the Princess of Wales to return to the hotel after they themselves left for the apartment in rue Arsne Houssaye at around 7pm. Henri Paul did not expect to return to the Ritz Hotel. It was only at the insistence of the night duty security officer, Franois Tendil, that he indicated he should be contacted by telephone if things changed. 9.40pm Dodi Al Fayed and the Princess of Wales had a table booked at the Chez Benot restaurant for around 9.30pm. The evidence showed that Dodi Al Fayed, while en route to the restaurant, changed these plans because of the unwelcome attention of the paparazzi. He decided to dine at the Ritz Hotel instead. He told his driver Philippe Dourneau to change destination. 9.52pm Dodi Al Fayed and the Princess of Wales arrived at the Ritz Hotel. The evidence of the security staff was that this was totally unexpected. It led to Dodi Al Fayed being unhappy at the lack of organisation as he and the Princess of Wales entered the hotel. 10pm Franois Tendil, the Ritz Hotel night security officer, telephoned Henri Paul on his mobile number and informed him of the couple's unexpected arrival. This was the first time that Henri Paul knew the couple had returned to the Ritz Hotel. Following the 10pm call he returned to the Ritz at 10.07pm. Ritz Hotel CCTV camera timings ; It follows that if Henri Paul had been with any intelligence security officers after leaving work at 7pm: i ; Before 10pm they could not have been planning a criminal operation, as Henri Paul did not expect to be returning to the Ritz Hotel that night. Henri Paul could not have predicted a change of plan by Dodi Al Fayed to change the restaurant venue. Henri Paul apparently returned immediately to the Ritz Hotel on being told of the couple's return by Franois Tendil approximately seven minutes from telephone call to arrival ; . He could have had no idea at that time what the new arrangements were, how long the couple would be there and what their intentions were. Hence, even if one were to accept a view that he had been accompanied by or in contact with intelligence security service officers on the journey to the Ritz Hotel, he only had approximately seven minutes to discuss the detail of potential plans to murder the Princess of Wales and Dodi Al Fayed before he arrived at the Ritz Hotel alone in his Mini evidence of CCTV cameras at the Ritz Hotel and sarafem.

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12 days ago in merpetsales · authority: 406 these are the rationales and outcomes of stress site. Cuba chairs latin american committee of the international geriatrics association havana, september 29 rhc ; - cuba will chair the latin american committee of the international geriatrics association for the next four years, in recognition of the island's work with the elderly. 6.2 Testing hypotheses about two proportions 123 and n4 153 smokers were treated with 100 mg of Zyban per day. The smokers in each group were treated with the placebo or the indicated dosage of Zyban for a period of seven weeks. The investigators recorded the number of smokers in each group who were still not smoking after one year were continuously abstinent for one year ; . Based on the evidence from this study we want to decide whether Zyban is effective as an aid to smoking cessation. More specifically, we want to determine whether the data support the contention that the probability that a smoker, who wanted to quit smoking, would be able to quit smoking and still not be smoking after one year if the smoker was treated with Zyban is greater than the corresponding probability if the smoker was treated with a placebo. First consider a comparison for the placebo treatment and the 300 mg per day Zyban treatment. We can envision two hypothetical populations based on this group of 615 smokers and these two experimental treatments. Since these 615 smokers do not form a random sample from some well defined population of smokers we must be careful to restrict our inferences to these 615 smokers. Extrapolation beyond this group cannot be justified on statistical grounds. Let p1 denote the proportion of this group of 615 smokers who would still not be smoking after one year if all 615 smokers were subjected to the seven week placebo treatment. Let p2 denote the proportion of this group of 615 smokers who would still not be smoking after one year if all 615 smokers were subjected to the seven week 300 mg per day Zyban treatment. In terms of these parameters our research hypothesis is H1 : and our null hypothesis is H0 : Nineteen of the n1 153 smokers in the placebo control group were still not smoking after one year and 36 of the n2 156 smokers in the 300 mg per day Zyban treatment group were still not smoking after one year. The two sample proportions of smokers still not smoking after one year are p1 .1242 and p2 .2308. Since both n1 and n2 are reasonably large and since p2 is almost twice as large as p1 , there appears to be sufficient evidence to conclude that p2 exceeds p1 ; but, let's perform a hypothesis test to be sure and to quantify this claim. The calculated Zstatistic is Zcalc -2.4490 which yields a P value of P value P Z -2.4490 ; .0072. Since the P value .0072 is very small, we find that there is very strong evidence that p 2 , the proportion of this group of 615 smokers who would still not be smoking after one year if all 615 smokers were subjected to the seven week 300 mg per day Zyban treatment, is greater than p1 , the proportion of this group of 615 smokers who would still not be smoking after one year if all 615 smokers were subjected to the seven week placebo treatment. In addition to this conclusion that p2 is greater than p1 we might also wish to estimate the difference between these two proportions to give an indication of how much better it is to take 300 mg per day of Zyban rather than a placebo. In this example we are 95.

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Despite noteworthy improvements in medical therapy, overall death rates for patients with hf have not declined appreciably. Analogously to the power decrease, a serious decrease of classification rate with increasing spontaneous rate p1 can be seen in Table 19. Class nave .671 .745 .823 Class boot .822 .841 .901 Power .325 .659 .853 non-centrality 0.03 0.05 0.07 Table 20: Classification rates and power for several non-centralities Alternative: 0.01 , nj 100 ; The increase of classification rates with increasing non-centrality is much steeper than the related power increase see Table 20 ; From these simulation can be concluded, The model classification is possible for one-inequality alternatives with rather high classification rate, particularly for the parametric bootstrap approach!

The Registrant did not respond to the Complaint within the twenty 20 ; day period within which the Registrant's response is to be filed pursuant to Rule 5 of the Rules. The BCICAC advised the Complainant of the lack of response by the Respondent and in accordance with Rule 6.5, the Complainant gave notice to the Service Provider, BCICAC to convert to a single member Panel. By letter dated August 9, 2004, the BCICAC acting in accordance with Paragraph 6 of the Rules named the Panel for this arbitration. As the Complaint was filed in English and as the Registrant has not responded, English is the designated language of the proceeding. LACK OF RESPONSE The Panel is advised by the BCICAC that the Complaint was communicated to the Registrant in accordance with the Rules and that no response has been received. Rule 5.8 provides that the Panel shall decide the matter on the basis of the complaint as submitted by the complainant in the event that the Registrant does not submit a response within the period for submission. Accordingly Rule 5.8 applies to the matter at hand and the Panel is determining the matter on the basis of the Complaint as filed by the Complainant. FACTS According to the Complaint, the Complainant, a subsidiary of GlaxoSmithKline "GSK" ; is the registered owner of the ZYBAN mark registered in the Canadian Intellectual Property Office December 15, 1998. GSK is the owner of the domain name ZYBAN which was registered March 18, 1997 and one of the leading research-based pharmaceutical and healthcare companies, working to discover, develop, manufacture and market medicines. Among GSK's numerous successful pharmaceutical products is the ZYBAN product, which has proven to be very effective in the treatment of smoking cessation and nicotine addiction and as a result has become famous in Canada and worldwide. According to its Annual Report for 2003, GSK generated sales of USD.2 billion worldwide, employs over 100, 000 people and spent USD billion on research and development in 2003. The ZYBAN website generates significant Internet traffic, a monthly average of over 20, 000 unique visitors based on a survey of visitor traffic between January 2004 and April 2004. As a result of extensive use and promotion predating the domain name registration, the ZYBAN mark has achieved vast and unparalleled public recognition and an exceptional reputation in Canada According to the Complaint, the Registrant specializes in search engine positioning services, and assists parties in achieving favourable Internet standing among search results, the whole as evidenced by copies of printouts of the Registrant's website located at dpmg and Internet advertising dated April 30, 2004. 6: 00 7: Group Run Walk- Led by Institute Chair and Director- Main Lobby Working Buffet Breakfast Tables by Topic- Salon III Child Adolescent Obesity; Healthy Dining at Work; Behavior Change & Coaching; CDC MCHB Activities & Update; Evaluating ROI; Pharmaceutical & Surgical Treatments; Your Health Plan: Untapped Resources; Best Employers for Healthy Lifestyles Awards Summit Kick-Off: Michael Davis, Institute Chair and Vice President, Human Resources, US Retail and Corporate, General Mills, Inc. - Salon III Employer Panel: Best Employers for Healthy Lifestyles Award Winners Tell Their Stories- Salon III Moderator: Lee Kidd, Vice President, Benefits, Tyson Foods, Inc. Jennifer Bruno, Director, Worldwide Wellness & Health Promotion, Johnson & Johnson John Zerbe, MD, Medical Director, GE Aviation Andy Scibelli, Manager, Health Management Program, Florida Power & Light. Breast cancer rates falling after a steady 20-year rise Among the exciting news was the announcement of a sevenpercent drop in breast cancer rates number of new breast cancers diagnosed annually ; in the United States in 2003, which could represent as many as 14, 000 cases a year. In Canada, rates decreased also, but by slightly less six percent ; . The decline seems to be mainly due to the large number of women in both the US and Canada ; who stopped taking hormone replacement therapy HRT ; to relieve menopausal symptoms following the release of the 2002 Women's Health Initiative trial results showing a link between HRT use and breast cancer, strokes and heart attacks. The benefit greatest fall in new breast cancer diagnoses ; was greatest for women between ages 50 and 69 with estrogen receptor-positive ER + ; cancers; this lends support to the HRT connection, since these tumours depend in part on hormones for growth and these were the tumours seen in association with HRT use. Research is continuing to try to confirm this welcome trend and rule out other possible causes. Meanwhile all women, but especially those who've had breast cancer, should talk to their doctor about the risks if they're considering taking HRT for menopausal symptoms. By the same token, women who really require HRT shouldn't stop taking it on their own before asking their doctor about possible ways to minimize the risks. Life tapes Chronic illnesses such as cancer are often accompanied by considerable stress and emotional anxiety, both for patients and their loved ones. While cancer sometimes brings families together, it can also often aggravate tensions and relationship problems. A poster presentation at SABCS described an interesting psychosocial intervention designed to increase communication and support between cancer patients and their loved ones. The Life Tapes Project began in 2002 and is sponsored by the Cancer Supportive Care Program at the University of California.
10. Koenig W., Sund M., Froehlich M. i wsp.: C-reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men. Circulation, 1999, 99, 237-242.
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